Organoids are Expected to be one of the Ethical Problems of Experimental Animals

doi:10. 3969 / j. issn. 1006-6179. 2024. 06. 001

Laboratory Animal Science ›› 2024, Vol. 41 ›› Issue (6): 1-4.DOI: 10. 3969 / j. issn. 1006-6179. 2024. 06. 001

( State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Education of Tianjin University of Traditional Chinese Medicine, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617,China)

Received:2023-11-14 Online:2024-12-28 Published:2025-01-15

类器官有望成为解决实验动物伦理问题的办法之一

(天津中医药大学组分中药国家重点实验室,天津中医药大学方剂学教育部重点实验室,天津中医药大学中医药研究院,天津 301617)

通讯作者: 朱金墙( 1985—) ,男,副研究员,主要从事中药防治心脑血管疾病的作用机制及药效物质基础研究、中药新药研究,E-mail:zhujinqiang1860@ 163. com。
作者简介:任美丹( 2000—) ,女,硕士研究生,主要从事类器官及卒中研究,E-mail:renmeidan158@ 163. com。
基金资助:
2024 年度组分中药国家重点实验室青苗基金项目(OMJJ202406)

Abstract

Abstract: The ethics of experimental animals has been a issue that cannot be ignored in animal experiments and attracts increasing attention. With the implementation of the “ 3R” ( replacement, reduction, refinement) principle of experimental animals and various laws and regulations guaranteeing the welfare of experimental animals, it is imperative to develop the replacement technology of experimental animals. In recent years, various organoid technologies have developed rapidly and shown great advantages, which is expected to be one of the ways to solve the ethical problems of experimental animals. This paper summarizes the problems in animal experiments and the development and application of organoids, in order to provide new ideas for the development of replacement technology of experimental animals and solve the ethical problems of experimental animals.

Key words: organoids, animal experiments, ethics of experimental animals, replacement techniques for experimental animals

摘要： 实验动物伦理问题一直是动物实验中不可忽视的问题,并越来越受关注。随着实验动物“ 3R” ( 替代、减少、优化)原则及各种保障实验动物福利法律法规的实施,发展实验动物替代技术势在必行。近年来各种类器官技术飞速发展,并展现出巨大优势,有望成为解决实验动物伦理问题的办法之一。本文综述了动物实验中存在的问题以及类器官的发展与应用,以期为实验动物替代技术的发展以及实验动物伦理问题的解决提供新的思路。

关键词: 类器官, 动物实验, 实验动物伦理, 实验动物替代技术

CLC Number:

Q95-3

REN Meidan, ZHU Jinqiang. Organoids are Expected to be one of the Ethical Problems of Experimental Animals[J]. Laboratory Animal Science, 2024, 41(6): 1-4.

任美丹, 朱金墙. 类器官有望成为解决实验动物伦理问题的办法之一[J]. 实验动物科学, 2024, 41(6): 1-4.

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